Dr. Stephania Cormier
Wiener Chair Professor
BMB/CDIB Division
Honorary Professor Child Health , University of Queensland, Australia
Honors BS - Biology and Chemistry, 1991, University of Louisiana
PhD - Biochemistry and Molecular Biology, 1997
Louisiana State University Medical Center
Fellowship: Pulmonary and Critical Care Medicine, Mayo Clinic Scottsdale, AZ
Office Phone: 225-578-9437 (ORED) / 225-763-2691 (PBRC)
Lab Phone: 225-578-9762 (PBRC)
Lab: PBRC
Office: L1016 PBRC / ORED 130 D. Boyd
E-mail: stephaniacormier@lsu.edu
Area of Interest
Respiratory Immunology & Toxicology
The main goal of my laboratory is to determine if exposure during early life to environmental factors (i.e. allergens, pollutants, and respiratory viruses) leads to predisposition, development of, or exacerbation of respiratory disease in the adult. We believe that adult respiratory diseases result, in part, from environmental impacts that occur during a critical phase of immuno-maturation. In the short term, we seek:
- to define the cellular and molecular changes in the pulmonary microenvironment following gestational and/or neonatal exposure
- to determine if urban pollutants (e.g. particulates such as diesel exhaust particles), initiate cellular/molecular events in the developing lung which lead to increased susceptibility to airways disease later in life
- to define the impact of respiratory viral infection on pulmonary pathophysiology of the infant; and
- to understand how urban pollutants impact host defense resulting in enhanced morbidity and increased mortality from respiratory infections
The long-term objective of my laboratory is to realize the initiators of the immune and pathophysiological changes that occur during the early stages of pulmonary airways disease and ultimately to develop effective interventions and therapies.
Selected Publications
Environmental Impacts on COVID-19: Mechanisms of Increased Susceptibili
SA Cormier, A Yamamoto, KR Short, L Vu, WA Suk
Annals of Global Health 88 (1)
Genomic Basis for Individual Differences in Susceptibility to the Neurotoxic Effects
of Diesel Exhaust
A Noël, DG Ashbrook, F Xu, SA Cormier, L Lu, JP O’Callaghan, ...
International Journal of Molecular Sciences 23 (20), 12461
Beyond the Unknown: A Broad Framing for Preparedness for Emerging Infectious Threats.
RC Christofferson, SA Cormier
The American Journal of Tropical Medicine and Hygiene, tpmd220341-tpmd220341
Metal-Free Biomass-Derived Environmentally Persistent Free Radicals (Bio-EPFRs) from
Lignin Pyrolysis
L Khachatryan, M Barekati-Goudarzi, R Asatryan, A Ozarowski, D Boldor, ...
ACS omega 7 (34), 30241-30249
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates
particulate matter-induced lung metastasis
J Liu, S Li, X Fei, X Nan, Y Shen, H Xiu, SA Cormier, C Lu, C Guo, S Wang, ...
Autophagy 18 (5), 971-989
IL-1β Promotes Expansion of IL-33+ Lung Epithelial Stem Cells after Respiratory Syncytial
Virus Infection during Infancy
LD Vu, ATQ Phan, DR Hijano, DT Siefker, H Tillman, SA Cormier
American Journal of Respiratory Cell and Molecular Biology 66 (3), 312-322
IL-1β Promotes Expansion of IL-33+ Lung Epithelial Stem Cells Following RSV Infection
During Infancy.
LD Vu, ATQ Phan, DR Hijano, DT Siefker, H Tillman, SA Cormier
American Journal of Respiratory Cell and Molecular Biology
The interplay between environmental exposures and COVID-19 risks in the health of
children
PD Sly, BA Trottier, CM Bulka, SA Cormier, J Fobil, RC Fry, KW Kim, ...
Environmental Health 20 (1), 1-10
Exposure to combustion derived particulate matter exacerbates influenza infection
in neonatal mice by inhibiting IL22 production
A Kumar, VS Patel, JN Harding, D You, SA Cormier
Particle and Fibre Toxicology 18 (1), 1-11
Association between particulate matter containing EPFRs and neutrophilic asthma through
AhR and Th17
JN Harding, M Gross, V Patel, S Potter, SA Cormier
Respiratory Research 22 (1), 1-16
Age Dependent Reduction of Neutralization Capacities Against Delta Variant Five Months
Post-Vaccination (BNT162b2)
LD VU, S Wallace, A Phan, RC Christofferson, E Turner, S Parker, ...
Reduced turnaround times through multi-sectoral community collaboration during the
first surge of SARS-CoV-2 and associated effect on patient care and hospital operations
RC Christofferson, HR O’Neal, T Jagneaux, C O’Neal, CS Walsh, ...
Plos one 16 (10), e0257302
Particulate matter exposure predicts residence in high-risk areas for community acquired
pneumonia among hospitalized children
TJ Oyana, J Minso, TL Jones, JA McCullers, SR Arnold, SA Cormier
Experimental Biology and Medicine 246 (17), 1907-1916
Integrative Cardiovascular Physiology and Pathophysiology: Deficiency in ST2 signaling
ameliorates RSV-associated pulmonary hypertension
LD Vu, J Saravia, S Jaligama, RVB Panday, RD Sullivan, S Mancarella, ...
American Journal of Physiology-Heart and Circulatory Physiology 321 (2), H309
Deficiency in ST2 signaling ameliorates RSV-associated pulmonary hypertension
LD Vu, J Saravia, S Jaligama, RV Baboeram Panday, RD Sullivan, ...
American Journal of Physiology-Heart and Circulatory Physiology 321 (2 …
The Effect of Combustion Generated Environmentally Persistent Free Radicals on Well-Differentiated
Human Airway Epithelial Cells
A Yamamoto, AJ Yeo, PD Sly, SA Cormier, S Lomnicki, L Khachatryan, ...
TP109. TP109 COPD AND E-CIGARETTES: PRE-CLINICAL MODELS AND MECHANISMS …
EFFECT OF ENVIRONMENTALLY PERSISTENT FREE RADICALS ON HUMAN AIRWAY EPITHELIUM
A Yamamoto, A Yeo, P Sly, S Cormier, L Khachatryan, F Hasan, E Fantino
RESPIROLOGY 26, 142-142
Developmental Hazard of Environmentally Persistent Free Radicals and Protective Effect
of TEMPOL in Zebrafish Model
X Guan, L Truong, S M. Lomnicki, R L. Tanguay, S A. Cormier
Toxics 9 (1), 12
Combustion by-products and their health effects: Summary of the 16th international
congress
A Violi, S Cormier, B Gullett, S Jansson, S Lomnicki, C Luyet, A Mayer, ...
Fuel 283, 118562